KMID : 1155520120070040338
|
|
Anesthesia and Pain Medicine 2012 Volume.7 No. 4 p.338 ~ p.342
|
|
The neuroprotective effect of colloids in forebrain ischemia model
|
|
Sohn Hye-Min
Jeon Young-Tae Hwang Jung-Won Park Hee-Pyoung Lim Young-Jin Kang Sun-Hye
|
|
Abstract
|
|
|
Background:The aim of this study was to investigate the neuroprotective effects of colloids (albumin and pentastarch) after forebrain global ischemia in rats. Methods:Thirty male Sprague-Dawley rats were randomly assigned to three groups; control, albumin and pentastarch group (each n = 10). Forebrain ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension. The control group received no treatment. The albumin group received 5 ml/kg of 20% albumin after ischemia. The pentastarch group received same volume of albumin after ischemia. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus. Results:The mean percentage of viable cells in the hippocampal CA1 area was significantly higher in the albumin (47%) compared with the control group (33%) or pentastarch group (33%) (P = 0.001). The percentage of apoptotic cells was significantly lower in the albumin (30%) group than that in the pentastarch (44%) or control group (49%) (P = 0.006). Conclusions:This study shows that albumin can improve histologic outcomes after forebrain global ischemia compared with pentastarch. (Anesth Pain Med 2012; 7: 338¡342)
|
|
KEYWORD
|
|
Albumin, Brain ischemia, Hippocampus, Pentastarch
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|